Year Development
1974 SANGI Co., Ltd. established in Tokyo
1976 NASA patent acquired
1978 First laboratory, producing hydroxyapatite
1980 Central Research Laboratory established
World’s first hydroxyapatite remineralizing toothpaste APADENT launched
1982- 1985 Anticaries field trials among Japanese schoolchildren
Second toothpaste brand APAGARD launched
1993 SANGI’s ingredient officially approved as an anticaries agent (“Medical Hydroxyapatite” (<mHAP>))
1995 TV advertising : SANGI's toothpaste captures 20% Japanese market share
1996 Relocation and expansion of Central Research Laboratory
2003 <mHAP> reduced from 3-figure to 2-figure nanoparticle size, enhancing remineralization and natural whitening capability
2004 “RENAMEL” brand launched exclusively for the dental route
2005SANGI's hydroxyapatite catalyst project (ethanol to butanol) awarded a development grant from Japan's New Energy and Industrial Technology Development Organization (NEDO)
2007 SANGI's 70th hydroxyapatite-related patent registered
2009 ISO 9001:2000 certification
2010SANGI's next-generation hydroxyapatite powder jet deposition project (PJD), in conjunction with Tohoku University, wins a 4-year development grant from Japan's Science and Technology Agency (JST)
2011 Toothpaste exports begin, to Russia (APADENT and later APAGARD)
Toothpaste exports expanded, to Canada (OEM brand)
Company 40th anniversary celebrations
APAGARD's 20th successive year as top-selling brand in Japan’s high-end “esthetic whitening” toothpaste market segment 
Toothpaste exports expand to China and Southeast Asia (both brands)
APAGARD PREMIO awarded the first Most Popular Toothpaste ranking by Japan's top consumer product opinion site @Cosme
Establishment of subsidiary SANGI Europe GmbH
APAGARD PREMIO wins third successive Most Popular Toothpaste ranking, raising it to @cosme's Hall of Fame status
Launch of sales in the EU (both brands)
SANGI sponsors the first Nano-Hydroxyapatite Technologies in Dentistry Symposium at the International Association of Dental Research (IADR) meeting in London
Launch of SANGI's skincare brand HAP+R in Japan
2019 SANGI's nano-hydroxyapatite remineralizing toothpaste sales since 1980 top 150 million tubes
2020 SANGI's export destinations reach 19 countries
SANGI EU online-shop launched
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